Resveratrol reference formula at an example amount of 100 mg per serving, developed as a capsule or softgel.
Resveratrol is a reference formula for brands building a single-ingredient resveratrol product around an example amount of 100 mg per serving. The brand sets the final amount for its market, and reference labels span 30 to 1,500 mg per serving, so the example is a starting point rather than a standard.
Capsule is the lead format and softgel is developed alongside. The work centers on a light-sensitive polyphenol that dissolves poorly in water and in oil: the raw material grade, the protection from light and the way the powder is dispersed decide the fill, the assay and the shelf life.
| Ingredient | Per Serving | Raw Material Form | Alternative Form (same amount of active) |
|---|---|---|---|
| Resveratrol | 100 mg (example amount) | Trans-Resveratrol 99%, specified as trans-resveratrol; 100 mg per serving | Japanese Knotweed Extract 20–50% Resveratrol, with the input recalculated from its resveratrol content |
The amount is stated as mg of resveratrol. Resveratrol is C14H12O3, 228.24 g/mol (PubChem CID 445154); it is used as the free polyphenol, so there is no salt or hydrate conversion.
This formula is designed for products positioned around polyphenol nutrition in healthy aging programs. Resveratrol is included as the single ingredient so that the concept stays on one well-studied polyphenol.
| Intended Benefit Direction | Key Ingredients | Formulation Rationale |
|---|---|---|
| Polyphenol antioxidant | Resveratrol | An umbrella review of resveratrol supplementation describes resveratrol as a compound that has shown antioxidant and anti-inflammatory effects, and summarizes 45 systematic reviews of randomized trials to resolve conflicting findings [1]. Evidence: Referenced |
| Cardiometabolic markers | Resveratrol | The same umbrella review reports 35 significant associations among 129, of which four were supported by high-certainty evidence: a smaller waist circumference, lower total cholesterol among overweight adults, and lower diastolic and systolic blood pressure among patients with type 2 diabetes [1]. Evidence: Mixed |
The amount is an example. The review in [1] pools trials of many doses and does not test this formula, so any claim on a finished product is reviewed for each market.
Reference labels are mostly capsules, with softgels and powders behind them; capsule and softgel are developed here.
| Format | Unit | Per Serving | Pack Size | Other Ingredients (typical) | Suitability |
|---|---|---|---|---|---|
| Capsule | 1 vegetable capsule | Resveratrol 100 mg | 60 or 90 capsules | Vegetable capsule shell, rice flour, flow agent | Lead format; light-protected bottle |
| Softgel | 1 softgel | Resveratrol 100 mg | 60 softgels | Gelatin or plant-based shell, glycerin, oil, lecithin | Powder suspended in an oil fill |
Design estimates. Trans-resveratrol is taken at 99% purity, so 100 mg of resveratrol needs about 101 mg of the 99% powder (100 ÷ 0.99); the supplier’s certificate replaces this once the lot is chosen.
| Format | Raw Material Input per Unit | Design Fill | Balance for Excipients | Verification Before Scale-Up |
|---|---|---|---|---|
| Capsule | Trans-resveratrol 99% 101 mg | 220 mg per capsule | 119 mg | Light-protected assay, capsule weight spread, release in a dissolution medium |
| Softgel | Trans-resveratrol 99% 101 mg | 500 mg fill | 399 mg | Suspension homogeneity in the oil, softgel weight spread, assay after storage |
Tablet, liquid and gummy are separate projects, because a poorly soluble polyphenol needs its own compression, dispersion and taste work in those systems.
Brands adjust the amount, the grade, the format and the add-ons.
| Parameter | Range | Note |
|---|---|---|
| Resveratrol per serving | 100, 250 or 500 mg | Examples for the brand; unit weight rises with the amount |
| Grade | Trans-resveratrol 99% or knotweed extract | Changes the input weight and the color |
| Format | Capsule or softgel | Tablet, liquid and gummy are separate projects |
| Add-ons | Quercetin, pterostilbene, NMN | A second ingredient changes the fill weight and the claim wording |
The pilot run confirms the trans-resveratrol assay after a light hold, capsule fill weight, and softgel suspension uniformity.
| Item | Status | Details |
|---|---|---|
| Reference formula | NIH DSLD | The ingredient and amount come from a labeled product in the NIH DSLD (100 mg on the label of CF007207; example DSLD labels 51150, 51151, 79851). The label names the ingredient as resveratrol; trans-resveratrol is set as the form. |
| Specification | Set in formulation | Trans-resveratrol at 100 mg per serving; trans-resveratrol assay, cis isomer limit, moisture, microbial and heavy-metal limits and method are fixed with the supplier. Unit size, fill weight and stability are set in formulation. |
| Data source | NIH DSLD | DSLD v9.4.0, downloaded 2026-01-10: 50,824 reference formulas merged from on-market labels with complete ingredient amounts. Counts show how labels are distributed. |
| Market review | Per market | Dose limits, labeling and claims are reviewed for each sales market before a finished product is developed. |
| References | Sources | [1] Sun JN, Yang R, Fang L, et al. Effects of resveratrol supplementation on multiple health outcomes: an umbrella review of systematic reviews and meta-analyses of randomized controlled trials. Nutr J. 2026;25(1):63. DOI · PubMed |
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