Grape Seed Extract

Single-ingredient grape seed extract reference formula at 200 mg per serving, developed as a capsule or powder.

Grape Seed is a reference formula for brands building a single-ingredient botanical extract product at a default amount of 200 mg of grape seed extract per serving. The extract is the only active ingredient, so the development work centers on the proanthocyanidin standardization of the extract, the astringent taste and color of a polyphenol powder, and the capsule or powder system that carries it.

Capsule is the lead format because 200 mg of extract fits one standard capsule, while the powder version serves brands that sell a stick pack or a drink mix. Options of 100, 400 and 1,000 mg sit beside the default, and the reference labels also include whole grape seed powders, which are different raw materials from a standardized extract, so the page is built around the extract.

Ingredient Composition

IngredientPer ServingRaw Material FormAlternative Form (same amount of active)
Grape Seed200 mg (default amount)Grape seed extract standardized to proanthocyanidins, for example the Grape Seed Extract 95% Oligomeric Proanthocyanidins (OPC) grade; specification 200 mg extract per serving, proanthocyanidin content set with the supplierGeneral Grape Seed Extract Powder with a different proanthocyanidin content, with the input recalculated so that the proanthocyanidin amount per serving is kept

Amounts are stated as mg of grape seed extract, not of proanthocyanidins. The proanthocyanidin amount per serving equals the extract weight multiplied by its assay, so a 200 mg serving of a 95% extract carries about 190 mg and a 40% extract about 80 mg, and the grade is part of the specification.

Intended Benefits & Formula Rationale

This formula is designed for products positioned around botanical polyphenol nutrition and healthy aging. Grape seed extract is included as the single active so that the standardization, the amount and the excipient system can be set without interaction with other actives.

Intended Benefit DirectionKey IngredientsFormulation Rationale
Botanical polyphenol nutritionGrape SeedIncluded because the seeds of grapes are rich in polyphenols, specifically proanthocyanidins, and a review describes pharmacological activities of grape seed extract in laboratory and experimental studies [2]. Evidence: Referenced
Circulatory studiesGrape SeedA meta-analysis of 19 controlled trials found that grape seed extract lowered diastolic blood pressure (-2.20 mmHg) and heart rate (-1.25 bpm), with no significant effect on flow-mediated dilation or systolic blood pressure and high heterogeneity between trials [1]. Evidence: Mixed

The extract weight is the stated amount, and the grade moves the dose of proanthocyanidins. The dose and duration in the trials of [1] were sources of heterogeneity, so amount, claims and target market are brand decisions reviewed for each sales market.

Available Formats

The grape seed reference formula is built for a capsule version and a powder version; counts per serving are design choices that the brand can adjust.

FormatUnitPer ServingPack SizeOther Ingredients (typical)Suitability
Capsule1 capsule200 mg extract60 or 120 capsulesRice flour, flow agent, vegetable capsule shellLead format; extract in a standard fill
Powder1 stick pack200 mg extract30 stick packsDiluent, citric acid, sweetener, flavorDrink mix; astringency needs masking

Raw Material Input & Fill (Design Estimate)

Design estimates. The input is the labeled extract weight at an assumed 100% assay of the extract as purchased, so 200 mg of extract per unit is used as the input; the proanthocyanidin content follows from the grade and is fixed in the specification.

FormatRaw Material Input per UnitDesign FillBalance for ExcipientsVerification Before Scale-Up
Capsule200 mg extract280 mg per capsule80 mgFlow, fill weight variation, proanthocyanidin assay, moisture
Powder200 mg extract2500 mg per stick2300 mgDispersion in water, astringency, color, proanthocyanidin assay

Tablet, softgel and gummy versions are separate projects, because an astringent, strongly colored polyphenol extract needs its own matrix and staining work in those systems.

Formulation Considerations

Grade sets the proanthocyanidin dose. A 200 mg serving carries from about 80 mg to about 190 mg of proanthocyanidins across the 40% to 95% range. The specification names the assay method, and a change of grade is a change of dose.
Astringency and color. Grape seed extract is reddish-brown, astringent and picks up moisture. A flavor and sweetener system in powders, shell color in capsules and blend humidity are set early, and staining of equipment is part of the cleaning plan.
Extract or seed powder. The reference labels pool extracts with whole seed powders at gram amounts. Powders carry far less proanthocyanidin per milligram, so they are kept as a separate project rather than an option on this page.
Evidence and tier. The meta-analysis in [1] reports non-linear relationships between blood pressure and both dose and duration, and the review in [2] draws on experimental studies. The amount tier is a market decision, and the dose limit for each sales market is reviewed before a product is developed.

Customization Options

Brands adjust the extract weight, the proanthocyanidin grade, the format and the add-ons.

ParameterRangeNote
Extract per serving100, 200, 400 or 1000 mgExamples for the brand; stick weight and capsule count follow the chosen tier
Proanthocyanidin grade40% to 95%Changes the proanthocyanidin dose per serving and the input weight
FormatCapsule or powderTablet, softgel and gummy are separate projects
Pack size30 to 120 unitsSet by the brand
Add-onsResveratrol, vitamin C, pycnogenolAnother polyphenol adds color and a second assay to the release plan

The pilot run confirms flow and fill weight of the extract blend, astringency and color in the powder version, and the proanthocyanidin assay of the first units against the specification.

Flavor Options

FormatSuggested FlavorsWhy
PowderGrape, berry, pomegranateFruit profiles that match the extract hide its astringency

Technical Status & Data Sources

ItemStatusDetails
Reference formulaNIH DSLDThe ingredient and amount come from a labeled product in the NIH DSLD (200 mg on the label of CF009489; example DSLD labels 72405, 252508, 252509). The label names the ingredient as grape seed extract; a proanthocyanidin-standardized extract is set as the form.
SpecificationSet in formulationGrape seed extract, 200 mg per serving, standardized to proanthocyanidins; assay, solvent residue, pesticide and heavy-metal limits and method are fixed with the supplier. Unit size, fill weight and stability are set in formulation.
Data sourceNIH DSLDDSLD v9.4.0, downloaded 2026-01-10: 50,824 reference formulas merged from on-market labels with complete ingredient amounts. Counts show how labels are distributed.
Market reviewPer marketDose limits, labeling and claims are reviewed for each sales market before a finished product is developed.
ReferencesSources[1] Foshati S, Nouripour F, Sadeghi E, et al. The effect of grape (Vitis vinifera) seed extract supplementation on flow-mediated dilation, blood pressure, and heart rate: A systematic review and meta-analysis of controlled trials with duration- and dose-response analysis. Pharmacol Res. 2022;175:105905. DOI · PubMed<br>[2] Gupta M, Dey S, Marbaniang D, et al. Grape seed extract: having a potential health benefits. J Food Sci Technol. 2020;57(4):1205-1215. DOI · PubMed

Related products

OEM/ODM Development Inquiry

Essencefield supports custom supplement formulation and OEM/ODM development, including ingredient selection, dosage adjustments, delivery formats, flavors, packaging, and commercial supply. Submit your project requirements below to explore customization options, sample development, and manufacturing solutions tailored to your brand and target market.