Yohimbe Bark Extract

Yohimbe bark reference formula with an example 250 mg per serving, developed as a powder, a capsule or a liquid, with the final amount set by the brand.

Yohimbe Bark is a reference formula for brands building a single-ingredient yohimbe product, with the bark extract declared by weight. The example serving carries 250 mg of yohimbe bark extract, and the brand sets the final amount, the yohimbine specification and the format for its market.

A powder carries the example amount, with capsules and liquids as the other main formats among the reference labels. The development work centers on the extract definition, the yohimbine alkaloid content that the extract is specified to carry, and the regulatory position of the ingredient in each sales market.

Ingredient Composition

IngredientPer ServingRaw Material FormAlternative Form (same amount of active)
Yohimbe Bark250 mg (example amount)Pausinystalia johimbe bark extract; specification 250 mg extract per serving, with yohimbine content, extraction ratio and plant part set with the supplierYohimbe bark powder at a higher weight, or an extract of a different yohimbine content at an adjusted weight

The amount is the weight of the extract as declared on the label, so the yohimbine content is part of the specification and is not inferred from the weight. The label names the ingredient as yohimbe bark extract; the bark is set as the plant part and the yohimbine assay as the identity test.

Intended Benefits & Formula Rationale

This formula is designed for products positioned around reproductive and hormonal wellness and traditional botanical use. Yohimbe bark extract is included as the single active so that the yohimbine content, the dose and the format can be set around one ingredient.

Intended Benefit DirectionKey IngredientsFormulation Rationale
Traditional botanical for men’s wellnessYohimbe BarkIncluded as a bark extract with a long history of use in men’s wellness products. Evidence: Product positioning
Erectile functionYohimbe BarkA systematic review and meta-analysis of eight studies of yohimbine in erectile dysfunction found a greater probability of improved erectile function than placebo (odds ratio 2.08, 95% CI 1.30 to 3.32 for yohimbine alone), while yohimbine alone did not show a significant difference in the rate of improved sexual function; the studies used yohimbine and not the bark extract [1]. Evidence: Referenced

The example amount is a starting point for development, and the final extract amount and format are settled with the brand for its market.

Available Formats

The reference formula is built for a powder, a capsule and a liquid version; counts per serving are design choices that the brand can adjust.

FormatUnitPer ServingPack SizeOther Ingredients (typical)Suitability
Powder1 stick pack250 mg yohimbe bark extract30 stick packsCarrier, natural flavorCarries the example amount; mixes into water
Capsule1 capsule250 mg yohimbe bark extract60 or 90 capsulesCapsule shell, flow agentCommon capsule format among the reference labels
Liquid1 mL250 mg yohimbe bark extract30 mL dropper bottlePurified water, glycerin, preservative systemDrops for brands that want a measured dose

Raw Material Input & Fill (Design Estimate)

Design estimates. The extract is assumed at 100% of the declared weight and a bulk density of 0.5 g/mL, so a size 1 capsule holds about 300 mg with a small flow agent allowance.

FormatRaw Material Input per UnitDesign FillBalance for ExcipientsVerification Before Scale-Up
Powder250 mg extract per stick2 g stick packAbout 1.75 g carrier and flavorBlend uniformity, moisture, taste, dissolution, yohimbine assay
Capsule250 mg extract per capsuleAbout 270 mg in a size 1 capsuleAbout 20 mg flow agentBulk density and flow, fill weight variation, yohimbine assay
Liquid250 mg extract per mL30 mL bottle (30 servings)Water, glycerin and preservative system to volumeSolubility at strength, assay, microbial stability

Tablet and gummy versions are separate projects, because an alkaloid-bearing extract needs its own compression and content uniformity study in those formats.

Formulation Considerations

Yohimbine content. The activity of a yohimbe extract is described by its yohimbine content. The specification names the assay and the method, and the serving is set from the assay so that the stated amount of yohimbine is the same from batch to batch.
Regulatory position. Yohimbe bark and yohimbine are treated differently across markets, and some markets restrict the ingredient or set limits on yohimbine. The sales markets are chosen first, and the market review is completed before a product is developed.
Bitterness and aroma. A bark extract is bitter. A flavor system and a sweetener are tested for the powder and liquid at the full serving.
Evidence and claims. The cited trials studied yohimbine in patients with erectile dysfunction and not a bark extract [1], so claims on a finished product are reviewed for each sales market before a product is developed.

Customization Options

Brands adjust the extract amount, the yohimbine specification and the format.

ParameterRangeNote
Extract per serving25 to 1881 mg across the reference labelsThe yohimbine assay decides the weight needed
Yohimbine specificationSet with the supplierSets the strength and the market fit
FormatPowder, capsule or liquidTablet and gummy are separate projects
Flavor systemUnflavored, citrus, berryUsed to cover the bitterness in the powder and liquid
Add-onsMaca, zincEvery add-on adds weight and affects the flow of the blend

The pilot run confirms the capsule fill weight, the powder dissolution and taste, the liquid stability and the yohimbine assay of the first fills.

Flavor Options

FormatSuggested FlavorsWhy
PowderCitrus, berry, unflavoredFruit notes cover the bark bitterness
LiquidCitrus, mintFresh notes soften the bitterness

Technical Status & Data Sources

ItemStatusDetails
Reference formulaNIH DSLDThe ingredient and amount come from a labeled product in the NIH DSLD (250 mg on the label of CF042874; example DSLD labels 311909, 311910, 311912). The label names the ingredient as yohimbe bark extract; the bark is set as the plant part.
SpecificationSet in formulationPausinystalia johimbe bark extract, 250 mg per serving; yohimbine content and method, loss on drying, heavy metal and microbial limits and methods are fixed with the supplier. Unit size, fill weight and stability are set in formulation.
Data sourceNIH DSLDDSLD v9.4.0, downloaded 2026-01-10: 50,824 reference formulas merged from on-market labels with complete ingredient amounts. Counts show how labels are distributed.
Market reviewPer marketDose limits, labeling and claims are reviewed for each sales market before a finished product is developed.
ReferencesSources[1] Wibowo DNSA, Soebadi DM, Soebadi MA. Yohimbine as a treatment for erectile dysfunction: A systematic review and meta-analysis. Turk J Urol. 2021;47(6):482-488. DOI · PubMed

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