Olive Leaf Extract

Single-ingredient olive leaf extract reference formula at 500 mg per serving, developed as a capsule, with a powder option at a 1,000 mg serving.

Olive Leaf is a reference formula for brands building a single-ingredient botanical extract product at a default amount of 500 mg of olive leaf extract per serving. The extract is the only active ingredient, so the development work centers on the oleuropein standardization of the extract, the fill weight of a bulky botanical powder and the label statements that go with an herbal ingredient.

Capsule is the lead format because a 500 mg extract fits one standard capsule, and a powder version at 1,000 mg serves brands that sell a drink mix. Olive leaf powders and standardized extracts are different raw materials, and the reference labels include both, so the page is built around the extract.

Ingredient Composition

IngredientPer ServingRaw Material FormAlternative Form (same amount of active)
Olive Leaf500 mg (default amount)Olive leaf extract standardized to oleuropein, for example the Olive Leaf Extract 10–40% Oleuropein grade; specification 500 mg extract per serving, oleuropein content set with the supplierA different oleuropein grade of the same extract, with the input recalculated so that the oleuropein amount per serving is kept

Amounts are stated as mg of olive leaf extract, not of oleuropein. Oleuropein is C25H32O13, 540.5 g/mol (PubChem CID 5281544). The oleuropein amount per serving equals the extract weight multiplied by its assay, so a 500 mg serving of a 10% extract carries about 50 mg of oleuropein and a 40% extract about 200 mg, and the grade is part of the specification.

Intended Benefits & Formula Rationale

This formula is designed for products positioned around botanical polyphenol nutrition. Olive leaf extract is included as the single active so that the standardization, the amount and the excipient system can be set without interaction with other actives.

Intended Benefit DirectionKey IngredientsFormulation Rationale
Traditional botanical nutritionOlive LeafIncluded because the olive leaf is considered an important traditional herbal medicine, and its polyphenols oleuropein, hydroxytyrosol and tyrosol are described with antioxidant and anti-inflammatory effects in laboratory studies [2]. Evidence: Referenced
Cardiometabolic studiesOlive LeafA meta-analysis of five trials in 325 adults with prehypertension or hypertension found no significant change in blood pressure with a combined 1,000 mg per day formulation, and a significant reduction in systolic blood pressure with 500 mg per day of olive leaf extract over at least 8 weeks [1]. Evidence: Mixed

The extract weight is the stated amount, and the grade moves the dose of oleuropein. The trials in [1] used both 500 and 1,000 mg per day, so amount, claims and target market are brand decisions reviewed for each sales market.

Available Formats

The olive leaf reference formula is built for a capsule version and a powder version; counts per serving are design choices that the brand can adjust.

FormatUnitPer ServingPack SizeOther Ingredients (typical)Suitability
Capsule1 capsule500 mg extract60 or 120 capsulesMicrocrystalline cellulose, vegetable stearate, silicon dioxide, capsule shellLead format; extract in a standard fill
Powder1 stick pack1000 mg extract30 stick packsDiluent, sweetener, flavor, anti-caking agentDrink mix; the bitter note needs masking

Raw Material Input & Fill (Design Estimate)

Design estimates. The input is the labeled extract weight at an assumed 100% assay of the extract as purchased, so 500 mg of extract per capsule is used as the input; the oleuropein content follows from the grade and is fixed in the specification.

FormatRaw Material Input per UnitDesign FillBalance for ExcipientsVerification Before Scale-Up
Capsule500 mg extract570 mg per capsule70 mgFlow, fill weight variation, oleuropein assay, moisture
Powder1000 mg extract3500 mg per stick2500 mgDispersion in water, bitterness, oleuropein assay

Tablet, softgel and gummy versions are separate projects, because a bulky, bitter leaf extract needs its own matrix and taste work in those systems.

Formulation Considerations

Grade sets the oleuropein dose. A 500 mg serving carries from about 50 mg to about 200 mg of oleuropein across the 10% to 40% range. The specification names the oleuropein assay, and a change of grade is a change of dose.
Bitter, hygroscopic extract. Olive leaf extract is bitter and picks up moisture. Capsule shell choice, blending humidity and, for powders, a sweetener and flavor system that covers the bitter note are set early.
Extract or leaf powder. The reference labels pool extracts with whole leaf powders at gram amounts. Powders carry much less oleuropein per milligram, so they are kept as a separate project rather than an option on this page.
Evidence and tier. The meta-analysis in [1] pooled few trials with different formulations and doses, and the review in [2] is based mainly on laboratory studies. The amount tier is therefore a market decision, and the dose limit for each sales market is reviewed before a product is developed.

Customization Options

Brands adjust the extract weight, the oleuropein grade, the format and the add-ons.

ParameterRangeNote
Extract per serving250, 500, 750 or 1000 mgExamples for the brand; capsule count or stick size changes with the tier
Oleuropein grade10% to 40%Changes the oleuropein dose per serving and the input weight
FormatCapsule or powderTablet, softgel and gummy are separate projects
Pack size30 to 120 unitsSet by the brand
Add-onsVitamin C, zinc, elderberryA second botanical adds fill weight and a second color and taste profile

The pilot run confirms flow and fill weight of the extract blend, taste masking in the powder version, and the oleuropein assay of the first units against the specification.

Flavor Options

FormatSuggested FlavorsWhy
PowderLemon, green apple, mintSharp, fresh profiles cover the bitterness of the leaf extract

Technical Status & Data Sources

ItemStatusDetails
Reference formulaNIH DSLDThe ingredient and amount come from a labeled product in the NIH DSLD (500 mg on the label of CF000063; example DSLD labels 708, 7185, 13004). The label names the ingredient as olive leaf extract; an oleuropein-standardized leaf extract is set as the form.
SpecificationSet in formulationOlive leaf extract, 500 mg per serving, standardized to oleuropein; oleuropein assay, solvent residue, pesticide and heavy-metal limits and method are fixed with the supplier. Unit size, fill weight and stability are set in formulation.
Data sourceNIH DSLDDSLD v9.4.0, downloaded 2026-01-10: 50,824 reference formulas merged from on-market labels with complete ingredient amounts. Counts show how labels are distributed.
Market reviewPer marketDose limits, labeling and claims are reviewed for each sales market before a finished product is developed.
ReferencesSources[1] Ismail MA, Norhayati MN, Mohamad N. Olive leaf extract effect on cardiometabolic profile among adults with prehypertension and hypertension: a systematic review and meta-analysis. PeerJ. 2021;9:e11173. DOI · PubMed<br>[2] Efentakis P, Iliodromitis EK, Mikros E, et al. Effects of the olive tree leaf constituents on myocardial oxidative damage and atherosclerosis. Planta Med. 2015;81(8):648-54. DOI · PubMed

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