L-tyrosine reference formula at a default of 500 mg per serving, developed as a capsule or powder.
L-Tyrosine is a reference formula for brands building a single-ingredient amino acid product around 500 mg per serving. The brand sets the final amount for its market, and reference labels span 350 to 2,500 mg per serving.
Capsule is the lead format because most reference labels use it, with a powder version developed for brands that prefer a drink mix. The work centers on an amino acid that dissolves poorly in water and has a bitter taste, which shapes the powder format more than the capsule.
| Ingredient | Per Serving | Raw Material Form | Alternative Form (same amount of active) |
|---|---|---|---|
| L-Tyrosine | 500 mg | L-tyrosine free-form powder, fermentation-derived, specified on a declared-weight basis; 500 mg per serving | N-acetyl-L-tyrosine, a different compound with its own specification and input calculation |
The amount is stated as mg of L-tyrosine. L-tyrosine is C9H11NO3, 181.19 g/mol (PubChem CID 6057); it is used as the free amino acid, so there is no salt or hydrate conversion.
This formula is designed for products positioned around amino acid nutrition for demanding days. L-tyrosine is included as the single ingredient so that the concept stays on one precursor amino acid.
| Intended Benefit Direction | Key Ingredients | Formulation Rationale |
|---|---|---|
| Neurotransmitter precursor nutrient | L-Tyrosine | A review describes tyrosine as the amino acid precursor of dopamine and norepinephrine [1]. Evidence: Referenced |
| Focus under demanding conditions | L-Tyrosine | The same review reports that studies of tyrosine supplementation vary considerably, that benefits to cognitive performance appear in short-term stressful or cognitively demanding situations, and that the potential to enhance physical exercise or treat clinical disorders seems limited [1]. Evidence: Mixed |
The amount is a design choice. The review in [1] covers tyrosine supplementation in general and does not test this formula, so any claim on a finished product is reviewed for each market.
Reference labels are mostly capsules, with powders behind them; capsule and powder are developed here.
| Format | Unit | Per Serving | Pack Size | Other Ingredients (typical) | Suitability |
|---|---|---|---|---|---|
| Capsule | 1 capsule | L-tyrosine 500 mg | 60, 90 or 120 capsules | Gelatin or vegetable capsule shell, stearic acid, silicon dioxide | Lead format; one capsule per serving |
| Powder | 1 scoop, 3 g | L-tyrosine 500 mg | 90 g tub (30 servings) | Sweetener, acid, flavor, flow agent | Drink mix; needs dispersion and taste work |
Design estimates. L-tyrosine is assumed at 100% of its declared weight, so 500 mg per serving needs 500 mg of raw material; the supplier’s assay is applied once the lot is chosen.
| Format | Raw Material Input per Unit | Design Fill | Balance for Excipients | Verification Before Scale-Up |
|---|---|---|---|---|
| Capsule | 500 mg | 540 mg per capsule | 40 mg | Powder flow and bulk density, fill weight variation, disintegration |
| Powder | 500 mg | 3 g per scoop | 2,500 mg | Dispersion and settling in water, taste, clumping |
Tablet, liquid and gummy are separate projects, because a 500 mg amino acid dose changes the compression work and the solubility limit sets the liquid format.
Brands adjust the amount, the form, the format and the add-ons.
| Parameter | Range | Note |
|---|---|---|
| L-tyrosine per serving | 500, 1000 or 1500 mg | Examples for the brand; capsule count or scoop size rises with the amount |
| Form | L-tyrosine or N-acetyl-L-tyrosine | Different compounds; input recalculated |
| Format | Capsule or powder | Tablet, liquid and gummy are separate projects |
| Add-ons | Vitamin B6, vitamin B12, caffeine | A second ingredient changes the fill weight and the claim wording |
The pilot run confirms the capsule size at the chosen powder lot, the settling behavior of the powder in water, and the assay of the first units against the label amount.
| Format | Suggested Flavors | Why |
|---|---|---|
| Powder | Citrus, tropical fruit, berry | Acidic fruit flavors cover the bitter note |
| Item | Status | Details |
|---|---|---|
| Reference formula | NIH DSLD | The ingredient and amount come from a labeled product in the NIH DSLD (500 mg on the label of CF000887; example DSLD labels 6393, 8914, 12484). The label names the ingredient as L-tyrosine; the free form is set. |
| Specification | Set in formulation | L-tyrosine free amino acid at 500 mg per serving; assay, specific rotation, moisture, microbial and heavy-metal limits and method are fixed with the supplier. Unit size, fill weight and stability are set in formulation. |
| Data source | NIH DSLD | DSLD v9.4.0, downloaded 2026-01-10: 50,824 reference formulas merged from on-market labels with complete ingredient amounts. Counts show how labels are distributed. |
| Market review | Per market | Dose limits, labeling and claims are reviewed for each sales market before a finished product is developed. |
| References | Sources | [1] Jongkees BJ, Hommel B, Kühn S, et al. Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands–A review. J Psychiatr Res. 2015;70:50-7. DOI · PubMed |
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