Hyaluronic Acid

Hyaluronic acid reference formula at an example amount of 100 mg per serving, developed as a capsule, powder or softgel.

Hyaluronic Acid is a reference formula for brands building a single-ingredient hyaluronic acid product around an example amount of 100 mg per serving. The brand sets the final amount for its market, and reference labels span 3 to 450 mg per serving.

Capsule is the lead format and powder and softgel are developed alongside. The work centers on the polymer itself: molecular weight, salt form and moisture uptake of a hygroscopic powder decide how it flows, fills and stays stable.

Ingredient Composition

Ingredient	Per Serving	Raw Material Form	Alternative Form (same amount of active)
Hyaluronic Acid	100 mg (example amount)	Hyaluronic acid as sodium hyaluronate powder, specified on a declared-weight basis; 100 mg per serving	Hyaluronic acid of a different average molecular weight, with the supplier’s grade stated on the specification

Amounts are stated as mg of hyaluronic acid powder at the declared weight. Hyaluronic acid is a polymer without a single molecular weight, so the specification names the average molecular weight range, the salt form and the content assay instead of a molecular-weight conversion.

Intended Benefits & Formula Rationale

This formula is designed for products positioned around beauty nutrition. Hyaluronic acid is included as the single ingredient so that the concept stays on one molecule.

Intended Benefit Direction	Key Ingredients	Formulation Rationale
Skin moisture	Hyaluronic Acid	A review reports that ingested hyaluronan increased skin moisture in a randomized, double-blind, placebo-controlled clinical study, and that part of the ingested hyaluronan is absorbed and distributed to the skin [1]. Evidence: Referenced

The amount is an example. The review in [1] summarizes the ingested hyaluronan studies it covers and does not test this formula, so any claim on a finished product is reviewed for each market.

Available Formats

Most reference labels are capsules, with powders and softgels behind them; these three formats are developed here.

Format	Unit	Per Serving	Pack Size	Other Ingredients (typical)	Suitability
Capsule	1 capsule	Hyaluronic acid 100 mg	60 or 90 capsules	Rice flour, microcrystalline cellulose, magnesium stearate, capsule shell	Lead format; low fill weight
Powder	1 stick pack, 3 g	Hyaluronic acid 100 mg	30 stick packs	Sweetener, acid, flavor, flow agent	Dissolves into a drink; needs moisture protection
Softgel	1 softgel	Hyaluronic acid 100 mg	60 softgels	Gelatin or plant-based shell, glycerin, oil	Powder suspended in an oil fill

Raw Material Input & Fill (Design Estimate)

Design estimates. The hyaluronic acid powder is taken at its declared weight, so 100 mg per serving needs 100 mg of raw material; the supplier’s content assay is applied once the grade is chosen.

Format	Raw Material Input per Unit	Design Fill	Balance for Excipients	Verification Before Scale-Up
Capsule	100 mg	350 mg per capsule	250 mg	Powder flow with moisture uptake, blend uniformity, fill weight variation, disintegration
Powder	100 mg per stick	3 g per stick pack	2,900 mg	Moisture uptake in the sachet, dissolution and clumping, taste
Softgel	100 mg	700 mg fill	600 mg	Suspension stability of the powder in the oil, fill weight variation, shell moisture exchange

Tablet and liquid are separate projects, because a high-molecular-weight polymer changes viscosity in a liquid and needs its own compression work as a tablet.

Formulation Considerations

Molecular weight grade. Hyaluronic acid is sold in a range of average molecular weights. The grade affects viscosity in water, powder flow and cost, so the specification fixes it before the formula is finalized.
Moisture uptake. The powder is hygroscopic. Humidity control during blending and filling, a moisture-barrier pack and a desiccant are part of the plan, and the capsule shell moisture window is checked.
Viscosity in a drink. In the powder format a polymer can thicken the drink and form lumps on contact with water. Particle size, a dispersing carrier and mixing instructions are tested in the pilot run.
Oil suspension. In a softgel the powder is suspended, not dissolved, so settling in the fill tank and uniform dosing across the batch are the main process risks.

Customization Options

Brands adjust the amount, the grade, the format and the add-ons.

Parameter	Range	Note
Hyaluronic acid per serving	50, 100 or 200 mg	Examples for the brand; fill weight rises with the amount
Molecular weight grade	Low, medium or high	Changes viscosity in a drink and the cost
Format	Capsule, powder or softgel	Tablet and liquid are separate projects
Add-ons	Vitamin C, collagen peptides	A second ingredient changes the fill weight and the blend plan

The pilot run confirms the powder flow of the chosen grade, the capsule fill weight, and the dissolution of the stick pack in water.

Flavor Options

Format	Suggested Flavors	Why
Powder	Lemon, berry, unflavored	Light fruit flavors suit a drink mix

Technical Status & Data Sources

Item	Status	Details
Reference formula	NIH DSLD	The ingredient and amount come from a labeled product in the NIH DSLD (100 mg on the label of CF005409; example DSLD labels 32293, 217875, 230472). The label names the ingredient as hyaluronic acid; sodium hyaluronate is set as the form.
Specification	Set in formulation	Sodium hyaluronate powder at 100 mg per serving; average molecular weight, content assay, moisture, microbial and heavy-metal limits and method are fixed with the supplier. Unit size, fill weight and stability are set in formulation.
Data source	NIH DSLD	DSLD v9.4.0, downloaded 2026-01-10: 50,824 reference formulas merged from on-market labels with complete ingredient amounts. Counts show how labels are distributed.
Market review	Per market	Dose limits, labeling and claims are reviewed for each sales market before a finished product is developed.
References	Sources	[1] Kawada C, Yoshida T, Yoshida H, et al. Ingested hyaluronan moisturizes dry skin. Nutr J. 2014;13:70. DOI · PubMed

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