Garlic Extract

Single-ingredient garlic extract reference formula at 500 mg per serving, developed as a tablet or capsule.

Garlic is a reference formula for brands building a single-ingredient botanical extract product at a default amount of 500 mg of garlic extract per serving. The extract is the only active ingredient, so the development work centers on the sulfur-compound standardization of the extract, the odor of a garlic raw material, and the coating or shell that carries it.

Tablet is the lead format because a 500 mg extract compresses into one coated tablet that contains the odor, and a capsule version carries the same extract in a standard fill. Garlic powders, aged garlic extracts and garlic oils are different raw materials, and the reference labels include several of them, so the page is built around a standardized extract.

Ingredient Composition

IngredientPer ServingRaw Material FormAlternative Form (same amount of active)
Garlic500 mg (default amount)Garlic bulb extract standardized to sulfur compounds, for example the Garlic Extract 1–5% Allicin / 3–5% Alliin grade; specification 500 mg extract per serving, allicin and alliin content set with the supplierAged Garlic Extract 0.5% S-Allyl Cysteine (SAC) as a separate specification with a different marker compound, or Garlic Powder for a whole-bulb product with a larger fill weight

Amounts are stated as mg of garlic extract, not of marker compounds. The marker amount per serving equals the extract weight multiplied by its assay, so a 500 mg serving of a 1% allicin extract carries about 5 mg of allicin and a 5% extract about 25 mg, and the grade and the marker compound are part of the specification.

Intended Benefits & Formula Rationale

This formula is designed for products positioned around botanical heart and circulatory nutrition. Garlic extract is included as the single active so that the standardization, the amount and the coating can be set without interaction with other actives.

Intended Benefit DirectionKey IngredientsFormulation Rationale
Traditional botanical nutritionGarlicIncluded because garlic has a long history in traditional Asian medicine and has been suggested to affect several cardiovascular risk factors, with antiplatelet and anticoagulant effects reported for garlic powder, aged garlic and garlic oil [2]. Evidence: Referenced
Lipid nutritionGarlicA meta-analysis of 108 randomized trials with 7,137 adults found a significant improvement in triglycerides (-5.82 mg/dL), total cholesterol (-10.21 mg/dL), LDL cholesterol (-5.90 mg/dL) and HDL cholesterol (+2.18 mg/dL) with garlic, and noted that earlier results had varied [1]. Evidence: Referenced

The extract weight is the stated amount and the grade moves the dose of marker compounds. The trials in [1] differ in preparation and dose, so amount, claims and target market are brand decisions reviewed for each sales market, together with the interaction note below.

Available Formats

The garlic reference formula is built for a tablet version and a capsule version; counts per serving are design choices that the brand can adjust.

FormatUnitPer ServingPack SizeOther Ingredients (typical)Suitability
Tablet1 tablet500 mg extract60 or 120 tabletsMicrocrystalline cellulose, croscarmellose sodium, stearic acid, silica, glycerin and hypromellose coatingLead format; coated unit that contains the odor
Capsule1 capsule500 mg extract60 or 90 capsulesVegetable capsule shell, flow agentExtract in a standard fill; odor control depends on the shell and the bottle

Raw Material Input & Fill (Design Estimate)

Design estimates. The input is the labeled extract weight at an assumed 100% assay of the extract as purchased, so 500 mg of extract per unit is used as the input; the marker compound content follows from the grade and is fixed in the specification.

FormatRaw Material Input per UnitDesign FillBalance for ExcipientsVerification Before Scale-Up
Tablet500 mg extract700 mg tablet weight200 mgCompression behavior, hardness, disintegration, coating integrity, marker assay
Capsule500 mg extract570 mg per capsule70 mgFlow, fill weight variation, odor, marker assay

Softgel, powder and gummy versions are separate projects, because a volatile sulfur ingredient needs its own odor and stability plan in those systems.

Formulation Considerations

Marker compound and grade. A 500 mg serving carries from about 5 mg to about 25 mg of allicin across the 1% to 5% range, and alliin or S-allyl cysteine are different markers. The specification names the marker and its assay, and a change of grade is a change of dose.
Odor and stability. Garlic sulfur compounds are volatile and the odor carries through bottles and packaging. A film-coated tablet, an enteric option, a sealed bottle and a desiccant are tested in stability work, and the marker content through shelf life is measured by assay.
Interaction note. A review reports antiplatelet and anticoagulant effects for garlic powder, aged garlic and garlic oil, through interference with cyclo-oxygenase-mediated thromboxane synthesis [2]. Label statements for each sales market are reviewed before a product is developed.
Extract, aged extract or powder. The reference labels pool extracts with whole-bulb powders and oil softgels. Aged garlic extract uses a different marker and a different safety profile, so it is a separate project rather than an option on this page.

Customization Options

Brands adjust the extract weight, the marker grade, the format and the coating.

ParameterRangeNote
Extract per serving400, 500 or 1000 mgExamples for the brand; unit size or count changes with the tier
Marker grade1% to 5% allicin, 3% to 5% alliinChanges the marker dose per serving and the input weight
FormatTablet or capsuleSoftgel, powder and gummy are separate projects
CoatingFilm coat or entericSets odor control and release behavior of the tablet
Add-onsCoenzyme Q10, hawthorn, vitamin K2A second active adds fill weight and a second odor and stability profile

The pilot run confirms tablet hardness and coating integrity, odor of the opened bottle, capsule fill weight and flow, and the marker assay of the first units against the specification.

Technical Status & Data Sources

ItemStatusDetails
Reference formulaNIH DSLDThe ingredient and amount come from a labeled product in the NIH DSLD (500 mg on the label of CF001926; example DSLD labels 12009, 27760, 56471). The label names the ingredient as garlic extract; a sulfur-compound-standardized bulb extract is set as the form.
SpecificationSet in formulationGarlic bulb extract, 500 mg per serving, standardized to allicin and alliin; marker assay, solvent residue, pesticide and heavy-metal limits and method are fixed with the supplier. Unit size, fill weight and stability are set in formulation.
Data sourceNIH DSLDDSLD v9.4.0, downloaded 2026-01-10: 50,824 reference formulas merged from on-market labels with complete ingredient amounts. Counts show how labels are distributed.
Market reviewPer marketDose limits, labeling and claims are reviewed for each sales market before a finished product is developed.
ReferencesSources[1] Behrouz V, Zahroodi M, Clark CCT, et al. Effects of Garlic Supplementation on Cardiovascular Risk Factors in Adults: A Comprehensive Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutr Rev. 2026;84(1):1-35. DOI · PubMed<br>[2] Rana SV, Pal R, Vaiphei K, et al. Garlic in health and disease. Nutr Res Rev. 2011;24(1):60-71. DOI · PubMed

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